Pharmaceutical IntermediateDG — Class 6.1

4-Aminophenol

Name: 4-Aminophenol
Brand: Chelora Pharmachem
SKU: CAS-123-30-8
Availability: InStock

CAS 123-30-8 · C₆H₇NO · MW 109.13

The key intermediate for manufacturing paracetamol — the world's most consumed analgesic. Chelora supplies verified, specification-grade 4-aminophenol with certificate of analysis and safety data sheet on every batch, for both domestic and export markets.

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IP & technical grades
COA with every batch
Domestic & export

Chemical manufacturing facility for 4-Aminophenol production

≥ 99 %

Pharma grade purity

CAS number

123-30-8

Formula

C₆H₇NO

Melting point

186 – 190 °C

Transport

UN 2512 · 6.1

Product overview

The backbone of paracetamol manufacturing

4-Aminophenol (also known as para-aminophenol or p-aminophenol) is an organic compound containing both an amine group (–NH₂) and a hydroxyl group (–OH) on a benzene ring. It is one of the most commercially important pharmaceutical intermediates globally, serving as the direct precursor to paracetamol (acetaminophen) — the world's most-prescribed over-the-counter analgesic and antipyretic.

Acetylation of 4-aminophenol with acetic anhydride produces paracetamol in a single synthetic step. Because the reaction is direct, the purity and consistency of the starting material has a decisive influence on the quality and yield of the finished API. Even small variations in moisture content, colour-forming impurities or residue on ignition can affect downstream tablet uniformity and dissolution.

Beyond pharmaceuticals, 4-aminophenol is consumed in oxidative hair dye formulation, silver-halide photographic developers, rubber antioxidant intermediates and azo dye chemistry — making it one of the most versatile phenol derivatives in the chemical industry.

Technical specifications

IUPAC name4-Aminophenol

Synonymsp-Aminophenol, para-Aminophenol, 4-Hydroxyaniline

CAS number123-30-8

Molecular formulaC₆H₇NO

Molecular weight109.13 g/mol

AppearanceWhite to light brown crystalline powder

Melting point186 – 190 °C

Solubility in waterSlightly soluble (≈ 1.1 g/100 mL at 20 °C)

Purity (assay)≥ 99.0 % (typical)

pH (1 % aqueous)5.0 – 7.0

Loss on drying≤ 0.5 %

Residue on ignition≤ 0.1 %

StorageCool, dry, well-ventilated area; protect from light

TransportUN 2512, Class 6.1, PG III

Applications & end uses

Where 4-Aminophenol is used

From life-saving medicines to everyday consumer products, 4-aminophenol enters a wide range of synthesis and manufacturing processes.

Paracetamol (acetaminophen) synthesis

4-Aminophenol is the principal intermediate in the manufacture of paracetamol, the world's most widely used analgesic and antipyretic drug. Acetylation of 4-aminophenol with acetic anhydride yields paracetamol in a single step, making the purity of this intermediate critical to the quality of the finished API.

Hair dye intermediates

Oxidative hair colourants rely on 4-aminophenol as a coupler that reacts with primary intermediates under peroxide activation to produce a range of warm and neutral tones. Cosmetic manufacturers require tight specifications on colour-forming impurities.

Photographic developers

In silver-halide photography, 4-aminophenol derivatives serve as developing agents that reduce exposed silver ions to metallic silver, producing the latent image. Although digital imaging dominates, specialist film and X-ray applications still consume significant volumes.

Rubber antioxidants & antidegradants

4-Aminophenol is a precursor for rubber antioxidants that protect vulcanised compounds from heat, ozone and flex cracking — extending the service life of tyres, belts and hoses.

Dye and pigment chemistry

As a versatile building block carrying both amine and hydroxyl groups, 4-aminophenol enters azo and sulphur dye synthesis routes used in textile, leather and ink manufacture.

Available grades

Choose the right grade for your process

Chelora supplies 4-aminophenol in the purity your application requires — from industrial use to pharmacopoeia-compliant API synthesis.

≥ 98.5 %

Technical grade

Industrial dyes, rubber chemicals

≥ 99.0 %

Pharma / IP grade

Paracetamol API synthesis

≥ 99.5 %

High-purity grade

Reference, photographic, research

Packaging options

Sealed, labelled and ready to ship

25 kg — HDPE-lined fibre drum

Standard bulk unit

50 kg — HDPE-lined MS drum

Cost-effective for larger volumes

Sample — Sealed HDPE container

QC evaluation before bulk order

Documentation supplied

Every document your QC team needs

Certificate of Analysis (COA)

Batch-specific assay, melting point, impurity and moisture results.

Safety Data Sheet (SDS)

GHS-format, 16-section SDS covering handling, storage and emergency measures.

Specification sheet

Agreed limit values for each test parameter.

Dangerous goods documentation

UN 2512 shipping papers for Class 6.1 transport.

Why source from Chelora

Confidence at every step of procurement

CAS-verified identity

Product name, CAS number and molecular formula confirmed against independent chemical databases before listing.

Batch-specific COA

Every shipment includes a certificate of analysis with assay, melting point, impurities and moisture results.

GHS-format SDS

Full 16-section safety data sheet prepared for your EHS and regulatory teams.

IP & technical grades

Grades matched to your application — from pharmacopoeia-compliant synthesis to industrial use.

Dangerous goods handling

Compliant packing, labelling and transport documentation for Class 6.1 shipments.

Export-ready supply

Documentation, labelling and packing prepared for international buyers across five regions.

Frequently asked questions

Common questions about 4-Aminophenol

What purity of 4-Aminophenol does Chelora supply?+

We supply 4-aminophenol at ≥ 99.0 % purity (pharma / IP grade) as standard. Technical grade (≥ 98.5 %) and high-purity grade (≥ 99.5 %) are available on request. Each batch ships with a certificate of analysis confirming the actual assay.

Is 4-Aminophenol classified as a hazardous material for shipping?+

Yes. 4-Aminophenol is classified as UN 2512, Class 6.1 (toxic), Packing Group III. Chelora prepares the required dangerous goods documentation and ensures compliant labelling and packaging for both domestic and international shipments.

Can I order a sample before placing a bulk order?+

Yes. We provide QC sample quantities in sealed HDPE containers so your laboratory can verify the material against your specification before you commit to a production volume.

What is the shelf life of 4-Aminophenol?+

When stored in a cool, dry, well-ventilated area and protected from light, 4-aminophenol typically retains specification for 24 months from the date of manufacture. Re-analysis can be arranged if stock approaches the retest date.

What is the lead time for a bulk order?+

Standard lead time is 7 – 14 working days depending on grade and volume. We provide dispatch updates and can often expedite for urgent requirements. Export orders include time for documentation and packing.

Do you export 4-Aminophenol outside India?+

Yes. We supply buyers across Asia-Pacific, the Middle East, Europe, Africa and the Americas. All export shipments include compliant labelling, SDS and dangerous goods paperwork.

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